Review article “Sex considerations in Regenerative Rehabilitation strategies for the treatment of knee osteoarthritis ” published in Current Opinion in Biomedical Engineering.
Regenerative rehabilitation is a promising field that aims to harness the regenerative potential of stem cell therapies to maximize functional recovery. This study explains recent advancements in regenerative rehabilitation for the treatment of knee osteoarthritis, with a particular focus on sex-specific considerations. A systematic review suggests that the functional decline of female mesenchymal stem cells (MSCs) is particularly pronounced after menopause, which may partly contribute to the sex differences in treatment efficacy. Although evidence is currently insufficient, physical stimulation has been shown to promote estrogen signaling in MSCs, potentially improving menopause-related MSC dysfunction. This study indicates that it is necessary to elucidate the effects of menopause and physical therapy on stem cell treatments to develop effective regenerative rehabilitation approaches.
The paper is available for free until July 5, 2024, so please take a look!